Mounjaro vs Ozempic: Which One Has Less Side Effects?

Nausea. Fatigue. Stomach issues. If you’re thinking about starting weight loss medication, you’re probably wondering if Mounjaro has less side effects than Ozempic, or vice versa, and how to avoid feeling worse before you feel better.

It’s a fair concern. Both medications can be incredibly effective for weight loss, but your experience can vary based on the dose, your body, and how closely you’re monitored during treatment.

In this article, we’ll unpack what the research says, what real patients experience, and why working with a supportive medical team—like the one at Bariendo—can make all the difference in how your body handles these medications.

Ready to explore your weight loss options with expert guidance? Discover how Bariendo can help you find a personalized, side-effect-conscious solution.

Does Mounjaro Have Less Side Effects Than Ozempic?

There’s no black and white answer to this question because no direct head-to-head trials have compared Mounjaro vs Ozempic side effects. But based on available research, Mounjaro (tirzepatide) appears to cause slightly fewer serious side effects than Ozempic (semaglutide) in clinical studies. 

That said, both medications share many of the same common side effects, and individual reactions can vary based on dose, health history, and how the medication is introduced.

What Clinical Research Says

Clinical trials for both Mounjaro (tirzepatide) and Ozempic (semaglutide) show that the most common side effects are gastrointestinal, including nausea, vomiting, diarrhea, constipation, and stomach pain. These symptoms tend to be dose-dependent and are often more noticeable when patients first start the medication or increase their dose.

In studies:

• Nausea was the most frequently reported side effect for both medications.
• Mounjaro users often reported slightly lower rates of nausea and vomiting compared to Ozempic users, though this varied by dose.
• Appetite loss and fatigue were also noted with both drugs, often seen as part of the weight loss effect but still challenging for some patients.

Overall, the research suggests that both medications share a similar side effect profile, but individual tolerance can vary. These studies are helpful, but they don’t reflect every real-world experience—which is where the next section comes in.

What Real Patients Experience

While clinical trials give us a good overview of what’s possible, real-life experiences with Mounjaro and Ozempic often paint a more personal and varied picture. Side effects can vary significantly from person to person, even when patients are on the same medication and dose.

Some patients report mild, short-term nausea that fades after a few weeks. Others may struggle with fatigue or GI discomfort for longer periods—especially if their dose increases too quickly. Although rare, some patients have reported itching at the injection site with these medications. In some cases, switching from one medication to the other helps reduce these symptoms, but this isn’t guaranteed.

That’s why ongoing medical supervision matters so much. With close monitoring, we can adjust timing, dosage, or even the medication itself to better fit your body’s needs—reducing side effects and improving your overall experience.

Most Common Side Effects of Mounjaro for Weight Loss

According to clinical studies and patient reports, the most common side effects of Mounjaro (tirzepatide) are related to digestion and appetite changes. These include:

• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Indigestion (dyspepsia)
• Stomach pain

These symptoms often appear during the first few weeks of treatment or after a dose increase. For many patients, they improve as the body adjusts. Starting at a lower dose and slowly increasing it, as typically recommended, can help reduce discomfort.

At Bariendo, we work closely with patients using Mounjaro to monitor side effects, offer symptom relief strategies, and ensure the medication is tolerated well over time.

Most Common Side Effects of Ozempic for Weight Loss

Like Mounjaro, Ozempic (semaglutide) is known for causing gastrointestinal side effects—especially when starting or increasing the dose. The most commonly reported include:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Constipation
• Tiredness/fatigue
• Burping or indigestion

These side effects are generally mild to moderate and tend to improve over time as the body adjusts. However, some patients may find Ozempic more difficult to tolerate—particularly if symptoms like nausea or fatigue persist with each dose increase.

In addition to common side effects, some patients have also reported other symptoms during treatment that aren’t officially documented but are discussed frequently in real-world settings. These include:

• Dry mouth
• Headaches or migraines
• Joint pain or back pain
• Muscle Pain
• Kidney stones
• Acne or skin breakouts

These symptoms are anecdotal and not confirmed in clinical trials. However, they may still be tied to how your body responds to rapid weight loss, dehydration, hormonal changes, or shifts in eating patterns.

At Bariendo, we take these concerns seriously. Whether a symptom is well-known or less common, our team works closely with patients to adjust doses, monitor side effects, and offer practical solutions—like hydration strategies, meal planning, and medical evaluations—to improve comfort and safety throughout treatment.

Do Mounjaro or Ozempic Cause Sexual Side Effects?

This is a common concern, but one that’s rarely addressed directly. Based on current research, neither Mounjaro (tirzepatide) nor Ozempic (semaglutide) are known to cause sexual side effects such as changes in libido, performance, or hormone levels.

There are no reports of sexual dysfunction or hormone disruption in the official clinical trials or prescribing information for either medication.

That said, some patients report mixed experiences after starting treatment:

• A few describe improved sexual health as they lose weight and gain energy.

• Others notice lower libido or increased fatigue, which may be linked more to side effects like nausea or low energy or poor lifestyle habits, rather than a direct impact from the medication itself.

If you experience changes in sexual health while using a GLP-1 medication, it’s worth discussing with your healthcare provider to discover the underlying cause.

Do Mounjaro or Ozempic Affect Mental Health?

You may also be wondering if weight loss medications like Mounjaro or Ozempic can impact your mood or mental health. According to clinical research and FDA-approved guidelines, these medications are not officially linked to mental health side effects such as anxiety, depression, or mood disorders.

However, some patients have shared anecdotal experiences of:

• Mood changes or irritability
• Fatigue and low motivation
• Brain fog
• Emotional ups and downs—especially early in treatment

These effects are usually temporary and are more likely tied to indirect factors like:

• Changes in eating habits or reduced calorie intake
• Nausea or poor sleep
• Dehydration or lower energy levels
• Rapid weight loss or hormonal shifts

In 2023, the European Medicines Agency began reviewing reports of suicidal thoughts linked to GLP-1 medications, but no direct connection has been proven, and regulatory guidelines have not changed.

If you notice changes in your mood, energy, or mental clarity while on Mounjaro or Ozempic, it’s important to bring it up with your provider. Mental health is just as important as physical health—and both should be supported during your weight loss journey.

Are Mounjaro and Ozempic Linked to Serious Adverse Events?

While most side effects of Mounjaro and Ozempic are mild and manageable, clinical trials have also tracked rare, but more serious adverse events with medications that contain the same active ingredients as Mounjaro and Ozempic. We can gain some insight by comparing Zepbound and Wegovy:

• Wegovy (semaglutide), which uses the same active ingredient as Ozempic but at higher doses, showed serious adverse events in 9.8% of participants.
• Zepbound (tirzepatide), the higher-dose version of Mounjaro, showed serious adverse events in 6.3% of participants.

While these numbers suggest Mounjaro may have a slightly lower rate of serious complications, it’s important to note that these figures came from separate studies with different patient groups, dosages, and trial designs. That makes an accurate direct comparison impossible.

While long-term data is still being gathered, current research shows that GLP-1s are generally safe and well-tolerated with proper medical oversight. The key takeaway is that serious side effects are rare with both active ingredients—but working with a care team ensures that any risks are monitored and managed early.

How Long Do Mounjaro and Ozempic Side Effects Last?

Most side effects from Mounjaro and Ozempic occur when starting the medication or increasing the dose. For many patients, symptoms like nausea, diarrhea, and fatigue improve within a few days to a few weeks as the body adjusts.

However, not everyone follows the same timeline. Some patients may continue to experience discomfort for longer—especially if doses are increased too quickly or if the medication isn’t well tolerated. For others, side effects may come and go with each dose escalation.

At Bariendo, we’ve found that slowing the dose increases, adjusting when the medication is taken, or pairing it with specific dietary changes can help reduce or shorten the duration of side effects. If symptoms persist for more than a few weeks, it’s worth having a conversation about whether a different dose—or a different approach—may be a better fit.

What to Know About Managing GLP-1 Side Effects

While Mounjaro and Ozempic are highly effective, managing their side effects well is key to long-term success. Here’s what patients need to understand about how these medications interact with their bodies.

Severity Increases with Higher Doses

GLP-1 medications are typically started at a low dose and gradually increased over time. That’s because side effects—especially nausea, vomiting, and stomach discomfort—often get worse at higher doses. Jumping too quickly to a higher amount can overwhelm the body and increase the risk of intolerable symptoms.

Dr. Pichamol “Sigh” Jirapinyo, co-founder at Bariendo, explains “Dose matters. We consistently see that side effects from both Ozempic and Mounjaro become more noticeable as the dosage increases. Carefully monitoring titration is key to patient comfort.”

Individual Tolerance Plays a Role

No two bodies respond exactly the same. Some patients experience very few side effects on these medications, while others may be more sensitive—even at lower doses.

Factors like metabolism, gut sensitivity, other medications, and pre-existing health conditions can all influence how a person tolerates Mounjaro or Ozempic. What works well for one person might not work for another.

Tips to Reduce Common Side Effects

Whether you’re starting Mounjaro or Ozempic, the first few weeks can come with some discomfort. Fortunately, many side effects can be managed—or even prevented—with the right approach.

Here are a few practical strategies we recommend to our patients at Bariendo:

• Start slow with dosing – Follow a gradual titration schedule to give your body time to adjust.
• Eat smaller, slower meals – Overeating or eating too fast can worsen nausea and stomach issues.
• Stick to bland, low-fat foods early on – Think broth, toast, rice, and lean proteins until your body adjusts.
• Stay hydrated – Dehydration can worsen fatigue, constipation, and headaches. Aim for water-rich foods and fluids throughout the day.
• Time your dose wisely – Some patients tolerate their medication better in the evening, when side effects are less disruptive.
• Avoid alcohol early on – Alcohol can intensify side effects and upset your stomach.
• Move gently – Light walking after meals can ease digestion and reduce bloating or discomfort.

Everyone’s body is different, which is why we work closely with each Bariendo patient to fine-tune their care plan for better results—and a more comfortable journey.

Medical Support is Crucial for the Best Experience

Managing GLP-1 side effects isn’t just about taking the right dose—it’s about being supported every step of the way. At Bariendo, we monitor how patients respond to medication, make real-time adjustments, and offer practical tips for managing side effects through food choices, hydration, and lifestyle changes.

Medication side effects don’t have to derail your progress. Learn how Bariendo’s supportive care model helps patients feel better—and see better results.

What Happens if You Switch Medications?

Some patients consider switching from Ozempic to Mounjaro for weight loss—or from Mounjaro to Ozempic—if they experience ongoing side effects. This can be a helpful option for some, but it’s not always a simple swap.

While both medications are GLP-1 receptor agonists, they’re structured differently and can affect the body in unique ways. A switch might result in fewer side effects, improved appetite control, or better weight loss—but it could also introduce new side effects your body hasn’t experienced before.

Switching should always be done under medical supervision, with proper timing, dose adjustments, and follow-up. At Bariendo, we help patients weigh the pros and cons, manage transitions carefully, and monitor how their bodies respond to the change.

What if GLP-1s Aren’t Enough?

GLP-1s can be incredibly helpful, but they don’t work for everyone. Some people experience ongoing side effects, reach a plateau, don’t see the results they hoped for, or simply get tired of ongoing monthly injections. When that happens, it’s natural to wonder if there’s an alternative to Ozempic and Mounjaro.

One of the most effective non-surgical options to consider is ESG Stomach Tightening™—a non-invasive, endoscopic procedure designed to help patients lose an average of 18% of their body weight. Unlike traditional bariatric surgery, ESG is performed through the mouth using a flexible endoscope. 

Developed by Dr. Christopher C. Thompson, a world-renowned endoscopist and co-founder of Bariendo, ESG was created to offer patients a long-term weight loss solution that fills the gap between medications and surgery. The benefits of ESG include:

• No incisions or scars
• Minimal downtime (most patients take 1-3 days off work)
• Proven durability, with results lasting 5+ years
• Slowed gastric emptying and fewer hunger hormones, which reduces cravings and helps you feel fuller longer
• No permanent alterations to the body means an easier recovery and possible reversal if unexpected complications arise
• Lower risk of complications compared to surgery
• More cost-effective than long-term GLP-1 use

ESG may cause temporary side effects like abdominal discomfort or nausea that typically resolve in a few days, unlike medication side effects which can last longer or worsen over time. It works by gently folding and tightening the stomach to reduce its size by up to 75% and control hunger naturally. It’s ideal for people who want real, sustainable results without the ongoing expense of medication or the risks of surgery.

At Bariendo, we pair ESG with expert follow-up care—giving you access to registered dietitians, nurse practitioners, and a care team that truly supports your long-term success.

Finding the Right Fit for Your Body and Your Goals

If you’re comparing Mounjaro vs Ozempic, it’s natural to be concerned about side effects—after all, how you feel day to day matters just as much as the number on the scale. While both medications share similar side effect profiles, your experience can depend heavily on the dose, your body’s unique response, and how well your care is managed.

There’s no one-size-fits-all answer. Some patients do better with one medication over the other. Others find that GLP-1s alone aren’t enough—and need a more durable solution like ESG Stomach Tightening™.

That’s where Bariendo comes in. We don’t just prescribe medications—we help guide your entire weight loss journey with expert care, ongoing support, and proven non-surgical options that put your health first.

Want expert help deciding between Mounjaro and Ozempic—or something better? Let’s build a treatment plan that’s safe, sustainable, and made for you.